The short answer
Yes. Rebuilt or re-downloaded automatically when needed.
What is it?
The standard place where apps store temporary, rebuildable data: downloaded images, thumbnails, web content, compiled files and update packages, one folder per app. It typically holds a few hundred MB to tens of GB, and macOS can clear some of it on its own when space runs low.
Temporary data apps rebuild. Some come back quickly; MoreRoom tracks that.
What happens if you delete it?
Apps rebuild their caches as they run. Some come back within minutes, so the space gained can be short-lived, and each app may start more slowly once.
How to remove it properly
Quit the apps whose caches you clear, then move their folders inside ~/Library/Caches to the Trash (Finder › Go › Go to Folder…). Prefer clearing the largest specific folders over everything at once, and restart afterwards.
Quit the app that uses it, then move it to the Trash. Empty the Trash when you’re sure.
Before you delete it
Do not delete the Caches folder itself, and avoid clearing caches of apps that are running. A few apps keep offline downloads in their cache, which then need downloading again.
How MoreRoom helps
MoreRoom recognises this item, shows its real size and when it was last used, and labels it “Safe to remove”. In the free version you can move it to the Trash in one click, with Undo; Pro collects every safe item at once.
Frequently asked questions
Is it safe to delete everything in ~/Library/Caches?
Yes. Rebuilt or re-downloaded automatically when needed. Apps rebuild their caches as they run. Some come back within minutes, so the space gained can be short-lived, and each app may start more slowly once.
Will App caches come back after I delete it?
Yes. Apps rebuild their caches as they run. Some come back within minutes, so the space gained can be short-lived, and each app may start more slowly once.
How do I remove App caches properly?
Quit the apps whose caches you clear, then move their folders inside ~/Library/Caches to the Trash (Finder › Go › Go to Folder…). Prefer clearing the largest specific folders over everything at once, and restart afterwards.